Liposomes
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Application of Liposome in Cosmetics
Liposome becomes the favorite in skin care community
Liposomes, bimolecular molecules composed of lipid-like hollow spheres, which are known as the new nanostructure for the encapsulation and delivery of bioactive agents in the medical field. Amid numerous brilliant drug delivery systems, liposomes provide a technology with accurate targeting, long-term efficacy and high stability to carry active molecules to the specific site of action, and now days, various formulations are in clinical use, and they are highly effective in treating diseases such as pain. Presently, with continuous in-depth research, liposomes have become one of the most available and popular products in cosmetic industry as the skin's trusted cosmetic ingredient transporters.
Liposomes have a more comprehensive effect on the skin
Since liposomes consist of phospholipids close to the structure of human skin that are similar to cell membranes, phospholipid double membranes can interact with and fuse with cell membranes, or intact liposomes are engulfed by cells while the active ingredient is released as well as fully absorbed. This natural structural advantage allows each nanoliposome to accurately find the skin target, penetrate deep into the skin to nourish and repair, and has a slow-release function to continuously deliver nutrients to the skin. Its specific utility is shown in the following aspects.
1) Encapsulation of functional ingredients such as collagen to help protect them from the action of body's enzymes and immune system, thus improving product stability.
2) Help break through the skin barrier and promote penetration of effective ingredients into the skin.
3) Promote the absorption of active ingredients by living cells
4) Help functional components release slowly in the body to achieve the purpose of long-lasting effect and reduce irritation, promote the skin for a long time to nourish and repair.
5) Its own ingredients can also reduce skin roughness, and the linoleic acid in phospholipids can replenish the skin with essential fatty acids and reduce the appearance of pimples and blackheads.
6) Has a moisturizing effect. No-load liposomes also keep the skin well hydrated.
Type of liposome
Liposomes can be divided into three types according to their morphology, small unilamellar vesicle (SUV), large unilamellar vesicle (LUV) and multilamellar vesicle (MLV)，and multivesicular vesicle (MVV).
1) The average particle size of SUV is between 20 and 200 nm, and the package capacity is small. In the liquid state, this liposome has high stability, and because the active ingredients contained in it are not easy to release, it has a good slow-release effect.
2) The average particle size of LUV is between 200 and 1000 nm. On the one hand, this kind of liposome has a high degree of coating. On the other hand, the particle size in this range has a high permeability, which can penetrate into the stratum corneum or deeper. However, due to possible fusion, the stability of large single compartment liposomes with an average particle size greater than 200 nm.
3) The average particle size of MLV is 1 to 5 µm. This kind of liposome has a high ability to penetrate the stratum corneum, and can carry hydrophobic and hydrophilic active ingredients at the same time.
4) The average particle size of MVV is greater than 1000 nm. MVV includes several small non concentric vesicles, embedded in a single lipid bilayer, which is very suitable for encapsulating a large number of hydrophilic materials
Practical use of liposome in cosmetic products
Liposomes are suitable for many types of cosmetic products, such as sunscreens and other cosmeceuticals. The addition of single compartment liposomes is not recommended for cream-type cosmetics, which generally contain a high number of surfactants, while MLV can be used as needed. LUV is preferred in skin care applications due to their high coverage. Cosmetics containing active ingredients with antioxidant and whitening effects, such as vitamin A, vitamin E and coenzyme Q10, are easily inactivated due to their own instability in the external environment or poor compatibility of formulated ingredients, notably, liposomes can play a significant role in cosmetic products due to their encapsulation and high permeability.
Formulation highlights
1) Avoid mixing liposome derivatives from different sources or manufacturers.
2) Avoid the use of a large number of solvents that can dissolve liposomes and water, such as glycerol and ethylene glycol, and the dosage in the formula should be controlled below 10%.
3) Avoid the use of anionic and nonionic surfactants in traditional formulations, which can form co-soluble components with liposomes.
4) Avoid the use of substances with high ionic strength, such as inorganic salts, which can destroy the bilayer molecular membrane.
5) Avoid high temperature operation, should be gently stirred below 50℃, high temperature will melt the double layer membrane, shear can cause the membrane to rupture.
As a leading cosmetic raw material supplier, Creative BioMart provides global customers with high-purity and cost-effective liposomes for the development of cosmetic and personal care products. We also have a wide variety of other raw materials that are versatile, such as collagen, growth factors, and botanical extracts, click to view our product catalog. Combining natural raw materials with innovative technologies, Creative BioMart aims to provide customers with superior products and solutions that meet current and future trends in the cosmetic market.
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References
- Panahi Y, et al. Recent advances on liposomal nanoparticles: synthesis, characterization and biomedical applications. Artif Cells Nanomed Biotechnol. 2017.
- Rahimpour Y, et al. Liposomes in cosmeceutics. Expert Opin Drug Deliv. 2012.
- Guimarães D, et al. Design of liposomes as drug delivery system for therapeutic applications. Int J Pharm. 2021.
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