Growth Factors

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Application of Growth Factor in Cosmetics

Effect of growth factors on skin

Growth factor (GF) is a cytokine that regulates the growth and development of different cells by binding with specific cell membrane receptors in vivo. It can prevent skin aging by stimulating collagen and elastin, and trigger the skin's innate healing ability. The most important GF involved in skin proliferation and remodeling are as follows:

1) Epidermal Growth Factor: Epidermal growth factor can promote cell proliferation, promote the synthesis of hyaluronic acid and elastic fibers, achieve skin rejuvenation, increase the transport of nutrients and sugar metabolism, thereby reducing and eliminating wrinkles. It is worth mentioning that it can also induce reverse differentiation of stem cells and repair wounds.

2) Fibroblast growth factor: Fibroblast growth factor stimulates and mediates angiogenesis and improves tissue ischemia. Promote the proliferation and migration of endothelial cells and fibroblasts, make new cells replace aging cells, and achieve wrinkle removal and anti-aging. Promote the synthesis and secretion of fibronectin. It is believed to promote skin cell growth and tissue repair.

3) Transforming growth factor-beta 1 and 2: It can regulate cell growth bidirectionally, promoting cell growth at low concentrations while inhibiting it at high concentrations. Promote the synthesis of extracellular matrices, such as hyaluronic acid and mucopolysaccharide. Repair of soft tissue injuries and inhibit scar hyperplasia.

4) Platelet-derived growth factor: Promote the chemotaxis of mesenchymal stem cells, fibroblasts, smooth muscle cells, macrophages, monocytes, and neutrophils. Promote fibroblast proliferation and migration; It is believed to regulate cell growth in wound healing.

5) Tissue inhibitor of metalloproteinases TIMP1, TIMP2: Regulates enzyme activity to prevent the breakdown of collagen and hyaluronic acid.

Application of Growth Factors in Cosmetics

Growth factors can be used in hydrogel, lotion, essence or injection form. Growth factors have been used many times in the medical application of wound healing and angiogenesis. These products are in injection or topical forms using hydrogel or stent systems. Because of its simple composition and high concentration ability, water-based essence dominates the cosmetics anti-aging market of EGF products for external use. The fixation and penetration enhancement of EGF must be achieved with the help of carriers in order to achieve more complex and multifaceted effects.

Clinical studies have shown that the application of growth factor has certain anti-aging effects, such as repairing, eliminating wrinkles, anti-aging, lightening stains and moisturizing. First, GF can be absorbed through sweat glands and hair follicles. Secondly, as the aging skin is drier and more fragile, even if it is intact, it is more vulnerable to the penetration of irritants and larger molecules. Finally, there is paracrine communication between keratinocytes and fibroblasts, and keratinocytes can induce fibroblasts to produce GF. The penetration of a small amount of locally applied GFs in the epidermis may promote GFs from platelets (TGF-α and TGF-β). It secretes and promotes the activation and proliferation of dermal fibroblasts, thus remodeling and regeneration of the extracellular matrix.

Other characteristics of growth factors

• The integrity of growth factors may be affected by pH and temperature, etc. Pay attention to storage conditions during application. The optimal pH ranges from 6.0 to 8.0, and the isoelectric point is about 4.6.
• One of the important factors affecting the stability of the growth factor formula is the interaction between solvent, excipient and ionizable group of the protein side chain. EGF is hydrophilic in nature and requires aqueous solvents. A final product concentration of 1 μ G/30g is considered appropriate and stable.
• Reducing sugar has the largest negative impact on the stability of EGF. PEG 6000 and polysorbate 20 and 80 have been proven to increase oxidation.

As a leading cosmetic raw material supplier, Creative BioMart provides global customers with high-purity and cost-effective growth factors for the development of cosmetic and personal care products. We also have a wide variety of other raw materials that are versatile, such as peptides, collagens, and botanical extracts, click to view our product catalog. Combining natural raw materials with innovative technologies, Creative BioMart aims to provide customers with superior products and solutions that meet current and future trends in the cosmetic market.

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References

1. Samizadeh S, et al. Effectiveness of growth factor-induced therapy for skin rejuvenation: A case series. J Cosmet Dermatol. 2021.
2. Husein El Hadmed H, et al. Cosmeceuticals: peptides, proteins, and growth factors. J Cosmet Dermatol. 2016.
3. Fabi S, et al. The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg. 2014.