Skin Toxicity Testing

Creative BioMart’s in vitro testing laboratories offer a range of cell based biological assays and non-cell-based approaches for safety and toxicity testing of raw materials and finished products for personal care products. In vitro test methods are key to safety assessment activities.

Health hazard effects of cosmetics mainly include:

(1) Acute toxicity: including acute toxic effects after oral, dermal or inhalation.

(2) Irritation: including skin irritation and eye irritation effects.

(3) Sensitization: mainly skin sensitization.

(4) Phototoxicity: including the phototoxicity and photosensitivity effects after ultraviolet radiation.

(5) Mutagenicity: including gene mutation and chromosome aberration effects.

(6) Chronic toxicity: including functional and/or organic changes to tissues and target organs after long-term exposure.

(7) Developmental and reproductive toxicity: including changes that cause fetal developmental abnormalities.

(8) Carcinogenicity: including the type, location and incidence of tumors.

Skin Toxicity Testing

Most of the toxicities are skin-related, thus rigorous dermatology studies are required to improve or introduce new skin care, cosmetic or beauty products to the market in order to assess their safety and efficacy. Prior to human use of new cosmetic products, in vivo animal tests are often conducted in order to screen for safety and efficacy. However, modern product development processes are rendering animal testing increasingly expensive and impractical. Furthermore, the tenets of ethical animal testing call for practice of the three R’s of refinement, reduction and replacement of animal tests. Therefore, a growing need exists for rapid and reliable in vitro methods for safety screening of new cosmetic formulations.

Creative BioMart provides in vitro skin assays using human/animal cells, submerged culture systems, 3D skin models, and 3D tissue models for acute toxicity tests. These tests are particularly evident in skin irritation, skin corrosion, and skin sensitization.

Consumer safety and satisfaction are key to bringing new or improved products to market and these can only be established through, scientifically credible dermatology trials. Our expert team can customize services according to customer needs.

Welcome to contact us for project quotations and more detailed information.

For R&D and Further Manufacturing ONLY.