Characterization of Nanotechnology in Cosmetics

Innovative nanotechnology is becoming more and more widely used in the cosmetics industry. Nanoparticles can change the optical properties of the products (for example, inorganic sunscreens look transparent when applied to the skin), and the encapsulated fragrance can perform better. In addition, nanostructures can:

• Protect cosmetic active substances from light or oxygen - especially beneficial to antioxidant molecules
• Overcome the problem of insolubility
• Control the release of substances
• Better efficacy

Many substances have been encapsulated in nanostructures, including retinoids, antioxidants, sunscreens (such as avobenzone), peptides, decolorants, etc. Nano-sized particles also can scatter UV, so they can act as physical UV filters. In addition to these advantages, nanoparticles generally have good hydration.

The EU Regulation (EC) No 1223/2009 requires manufacturers to list any nanoparticles contained in products marketed within the EU. Therefore, it is extremely important for manufacturers to characterize nanotechnology and evaluate the potential risks associated with nanomaterials, which is the basis for ensuring the safety of cosmetics accurately and efficiently.

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Nanotechnology-based formulations can provide various advantages for cosmetics, but may bring some challenges during the development process. The accurate characterization of nanocosmetics is a basic step in the development process, because the stability and performance of the product are closely related to this. To develop reliable and effective products, detailed analyses of multiple parameters of the products are required. Characterization techniques can determine information including average particle size and particle size distribution, polydispersity index, zeta potential, and morphology.

Creative BioMart’s nanotechnology scientists have extensive experience in nanoscience, and can provide customers with a series of advanced technologies to investigate whether there are nanosystems (including nanoparticles, nanoliposomes, nanoemulsions, and nanoactive species, etc.), and perform accurate characterization.

The cosmetic nanotechnology characterization technologies we provide include but are not limited to:

• Electron microscopy technology provides a useful visualization method for the determination of the shape and size of nanomaterial particles
• Electron microscopy can be used in conjunction with spectroscopy or spectrophotometry to provide more information about the particle size, shape, and chemical composition of nanomaterials
• SEM is combined with energy dispersive X-Ray diffraction (EDAX) to obtain elemental information of individual particles
• Particle size measurement (PSD) techniques, such as laser diffraction or disc centrifugation
• Cryo-SEM and cryo-preparation preserve the microstructure of nanoliposomes
• Dynamic light scattering and other PSD methods to measure the size of the dispersed liposomes
• High-performance liquid chromatography (HPLC)/ultra-performance liquid chromatography (UPLC) detection systems can quantify the level of actives

With the widespread application of nanotechnology in the cosmetics industry, analytical methods for the physical and chemical characterization of nanomaterials in cosmetics should meet the requirements of measurement purposes and have high accuracy. Creative BioMart's nanotechnology research platform combines a variety of advanced technologies to provide global cosmetic manufacturers with high-precision, high-reproducibility, and time-saving testing services.

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